Robert A Kesterson Selected Research

Neurofibromin 1 (Neurofibromin)

6/2022	Targeted exon skipping of NF1 exon 17 as a therapeutic for neurofibromatosis type I.
1/2022	Analysis of patient-specific NF1 variants leads to functional insights for Ras signaling that can impact personalized medicine.
6/2020	Mutation-Directed Therapeutics for Neurofibromatosis Type I.
1/2019	Affinity Purification of NF1 Protein-Protein Interactors Identifies Keratins and Neurofibromin Itself as Binding Partners.
1/2018	NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer.
1/2018	Neurofibromin (NF1) genetic variant structure-function analyses using a full-length mouse cDNA.

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Robert A Kesterson Research Topics

Disease

7	Obesity 05/2013 - 06/2003
6	Neoplasms (Cancer) 01/2021 - 10/2015
5	Neurofibromatosis 1 (Neurofibromatosis Type I) 06/2022 - 01/2018
4	Hyperphagia (Overeating) 09/2013 - 04/2005
3	Weight Gain 09/2013 - 04/2005
2	Brain Diseases (Brain Disorder) 01/2022 - 01/2021
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 06/2020
2	Insulin Resistance 01/2020 - 04/2005
2	Ciliopathies 01/2019 - 05/2013
2	Carcinogenesis 01/2018 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2018 - 10/2015
2	Disease Susceptibility (Diathesis) 10/2016 - 10/2013
2	Body Weight (Weight, Body) 10/2016 - 09/2013
1	Seizures (Absence Seizure) 01/2021
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2021
1	Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl) 01/2020
1	Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I) 01/2019
1	Retinal Degeneration 01/2019
1	Cystic Kidney Diseases (Cystic Kidney Disease) 01/2019
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Adenocarcinoma 01/2018
1	Osteoarthritis 10/2016
1	Osteoporosis 10/2016
1	Decapitation 04/2016
1	Male Infertility (Male Sterility) 04/2016
1	Optic Nerve Glioma 01/2016
1	Cataract (Cataracts) 01/2016
1	Oculocutaneous Albinism (Albinism, Yellow Mutant) 01/2016
1	Agenesis of Cerebellar Vermis 12/2015
1	Carcinoma (Carcinomatosis) 10/2015
1	Disease Progression 10/2015
1	Colonic Neoplasms (Colon Cancer) 11/2012
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 08/2010
1	Hyperinsulinism (Hyperinsulinemia) 12/2008
1	Hyperglycemia 08/2007
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2006
1	Glomerulonephritis 12/2006
1	Dermatitis 12/2006
1	Autoimmune Diseases (Autoimmune Disease) 12/2006
1	Pain (Aches) 07/2005
1	Glucose Intolerance 04/2005
1	Autistic Disorder (Autism) 04/2003

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 06/2022 - 04/2003
6	Neurofibromin 1 (Neurofibromin)IBA 06/2022 - 01/2018
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 04/2005
3	Mitochondrial DNA (mtDNA)IBA 10/2016 - 10/2013
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2018 - 08/2007
2	Risperidone (Risperdal Consta)FDA LinkGeneric 09/2013 - 03/2009
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 05/2013 - 09/2007
2	LeptinIBA 05/2013 - 04/2005
2	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 07/2005 - 06/2003
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 06/2022
1	trkB ReceptorIBA 01/2022
1	PoisonsIBA 01/2021
1	Sodium Channels (Sodium Channel)IBA 01/2021
1	necdinIBA 01/2021
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	Estrogens (Estrogen)FDA Link 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2018
1	CateninsIBA 01/2018
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2018
1	Estrogen ReceptorsIBA 01/2018
1	OsteocalcinIBA 10/2016
1	2'- (2- hydroxyphenyl)- 2'- thiazoline- 4'- carboxylic acidIBA 04/2016
1	Gemcitabine FDA Link 01/2016
1	CalpainIBA 01/2016
1	Crystallins (Crystallin)IBA 01/2016
1	Glial Fibrillary Acidic ProteinIBA 01/2016
1	Glycoproteins (Glycoprotein)IBA 01/2016
1	Neomycin FDA LinkGeneric 01/2016
1	Sialic AcidsIBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	Monophenol Monooxygenase (Tyrosinase)IBA 01/2016
1	GlycosyltransferasesIBA 01/2016
1	Leptin ReceptorsIBA 05/2013
1	ClusterinIBA 11/2012
1	5-HT2C Serotonin ReceptorIBA 08/2010
1	OrexinsIBA 03/2009
1	A-factor (Streptomyces)IBA 12/2008
1	LipidsIBA 12/2008
1	EnzymesIBA 08/2007
1	LigandsIBA 12/2006
1	P-selectin ligand proteinIBA 12/2006
1	P-SelectinIBA 12/2006
1	CC ChemokinesIBA 12/2006
1	Morphine (MS Contin)FDA LinkGeneric 07/2005
1	AdiponectinIBA 04/2005
1	PPAR gammaIBA 04/2005
1	Melanocortin Receptors (Melanocortin Receptor)IBA 06/2003
1	Amyloid (Amyloid Fibrils)IBA 04/2003

Therapy/Procedure

2	Therapeutics 01/2022 - 06/2020
1	Lenses 01/2016
1	Caloric Restriction 08/2007